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Validation of a novel partial resuscitative endovascular balloon occlusion of the aorta device in a swine hemorrhagic shock model: Fine tuning flow to optimize bleeding control and reperfusion injury
CONCLUSION Prolonged pREBOA at a moderate distal flow rate provided adequate hemorrhage control, improved survival, and had evidence of decreased ischemic injury versus fREBOA. Prophylactic aggressive calcium supplementation may have utility before and during the reperfusion phase.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - June 23, 2020 Category: Orthopaedics Tags: 2020 EAST PODIUM PAPER Source Type: research

Enhanced denitrification of dispersed swine wastewater using Ca(OH) < sub > 2 < /sub > -pretreated rice straw as a solid carbon source
Chemosphere. 2022 Jun 13:135316. doi: 10.1016/j.chemosphere.2022.135316. Online ahead of print.ABSTRACTIn a pilot-scale packed bed reactor, the denitrification performance and microbial community structure of the dispersed swine wastewater treatment using calcium hydroxide (Ca(OH)2) pretreated rice straw as a carbon source were investigated. In a Ca(OH)2-pretreated rice straw supported denitrification system (Ca(OH)2-RS), the removal efficiency of NO3--N was 96.39% at an influent NO3--N load of 0.04 kg/(m3•d). Meanwhile, there was no obvious accumulation of NO2--N or chemical oxygen demand (COD) in the effluent of Ca(OH)...
Source: Chemosphere - June 16, 2022 Category: Chemistry Authors: Lianhua Yuan Leilei Tan Zhiqiang Shen Yuexi Zhou Xuwen He Xuemin Chen Source Type: research

Lazaroid U-74389G Administration in Pancreatic Ischemia-Reperfusion Injury: A Swine Model Encompassing Ischemic Preconditioning.
CONCLUSION: This swine model of pancreatic ischemia and reperfusion, encompassing preconditioning, indicates that U-74389G lazaroid does not seem to exert protective effects from pancreatic damage. PMID: 25791552 [PubMed - in process]
Source: JOP - March 23, 2015 Category: Gastroenterology Authors: Chrysikos DT, Sergentanis TN, Zagouri F, Psaltopoulou T, Theodoropoulos G, Flessas I, Agrogiannis G, Alexakis N, Lymperi M, Katsarou AI, Patsouris ES, Zografos CG, Papalois AE Tags: JOP Source Type: research

Viruses, Vol. 10, Pages 460: Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum
Manuel V. Borca We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains and amino acid residues critical for pore formation. Here, we describe how p7 specifically interacts with host protein CAMLG, an integral ER transmembrane protein involved in intracellular calcium release regulation and signal response generation. Detection of interaction as well as the identification of p7 areas mediating interaction with CAMLG was performed by yeast two-hybrid. p7-...
Source: Viruses - August 28, 2018 Category: Virology Authors: Douglas P. Gladue Eneko Largo Lauren G. Holinka Elizabeth Ramirez-Medina Elizabeth A. Vuono Keith A. Berggren Guillermo R. Risatti Jose L. Nieva Manuel V. Borca Tags: Communication Source Type: research

Intracellular changes of a swine tracheal cell line infected with a Mycoplasma hyopneumoniae pathogenic strain
Publication date: Available online 5 September 2019Source: Microbial PathogenesisAuthor(s): Fernanda M.A. Leal Zimmer, Hercules Moura, John R. Barr, Henrique Bunselmeyer FerreiraAbstractMycoplasma hyopneumoniae is the etiological agent of enzootic pneumonia (EP), a widespread disease that causes major economic losses to the pig industry. The swine host response plays an important role in the outcome of M. hyopneumoniae infections. The whole proteome of newborn pig trachea (NPTr) epithelial cells infected with the M. hyopneumoniae pathogenic strain 7448 was analyzed using an LC-MS/MS approach to shed light on intracellular ...
Source: Microbial Pathogenesis - September 5, 2019 Category: Infectious Diseases Source Type: research

Toxicity and antimicrobial effect of silver nanoparticles in swine sperms.
Abstract Bacterial contamination in swine semen affects the quality and longevity of sperm and consequently fertility is reduced. Antibiotics have been used to prevent bacterial growth, but the frequency of bacterial resistance to various antibiotics are increasing. Silver nanoparticles (AgNPs) of 10-20 nm in size have shown a biocide effect in bacteria and fungi microorganisms without toxicity to certain mammalian cells. The goal of this study was to analyze both, antimicrobial activity against Staphylococcus aureus and toxicity in swine sperms after 10-20 nm AgNPs treatment. S. aureus proliferation decreased w...
Source: Systems Biology in Reproductive Medicine - May 25, 2020 Category: Reproduction Medicine Authors: Pérez-Duran F, Acosta-Torres LS, Serrano-Díaz PN, Toscano-Torres IA, Olivo-Zepeda IB, García-Caxin E, Nuñez-Anita RE Tags: Syst Biol Reprod Med Source Type: research

Metabolic Syndrome and SIRT1 Mutation Impair Ca < sup > 2+ < /sup > Channels in Coronary Smooth Muscle Cells of Ossabaw Miniature Swine
CONCLUSION: SIRT1L100P mutation is likely to contribute to coronary atherosclerosis and SIRT1 activators may be effective therapies.PMID:35553161 | DOI:10.1096/fasebj.2022.36.S1.R6137
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Aish Thamba John Reed John Strobel James Byrd Mouhamad Alloosh Alex Coutts Michael Sturek Source Type: research

Mp34-01 renal histopathology after calcium oxalate stone induction: crystalluric and tubular effects of high urinary oxalate excretion in a swine model
Swine are good models for stone disease as they closely resemble humans for gastrointestinal and renal morphology and function. We have developed a swine model that manifests hyperoxaluria and calcium oxalate (CaOx) stone formation via two methods: (1) enhanced oxalate (Ox) biosynthesis, from hydroxyproline (HYP) feeding; or (2) enhanced dietary Ox absorption (by feeding sodium oxalate). Histopathology characterized changes in crystalluric and renal tubular parameters in gilts (adult virgin sows) fed either HYP or Ox.
Source: The Journal of Urology - April 1, 2015 Category: Urology & Nephrology Authors: Kristina L. Penniston, Denise J. Schwahn, Thomas D. Crenshaw, Stephen Y. Nakada Tags: Stone Disease: Basic Research II Source Type: research

Effect of High-Calcium Diet on Coronary Artery Disease in Ossabaw Miniature Swine With Metabolic Syndrome Coronary Heart Disease
Conclusion There was no detectable effect of high calcium diets (from dairy or calcium carbonate) on coronary artery calcium deposition in metabolic syndrome swine.
Source: JAHA:Journal of the American Heart Association - August 13, 2015 Category: Cardiology Authors: Phillips-Eakley, A. K., McKenney-Drake, M. L., Bahls, M., Newcomer, S. C., Radcliffe, J. S., Wastney, M. E., Van Alstine, W. G., Jackson, G., Alloosh, M., Martin, B. R., Sturek, M., Weaver, C. M. Tags: Coronary Heart Disease Source Type: research

Effect of three different bariatric obesity surgery procedures on nutrient and energy digestibility using a swine experimental model
Morbid obesity is a worldwide health concern that compromises life quality and health status of obese human subjects. Bariatric surgery for treating morbid obesity remains as one of the best alternatives to promote excess weight loss and to reduce co-morbidities. We have not found studies reporting nutrients and energy balance considering digestibility trials in humans following surgery. The purpose of this study was to determine protein, lipid, fiber, energy, calcium, and phosphorous digestibility in a swine model that underwent ileal transposition (IT), sleeve gastrectomy with ileal transposition (SGIT), Roux-en-Y gastri...
Source: Experimental Biology and Medicine - September 10, 2015 Category: Research Authors: Gandarillas, M., Hodgkinson, S. M., Riveros, J. L., Bas, F. Tags: Endocrinology and Nutrition Source Type: research

The Network of Interactions Between Classical Swine Fever Virus Nonstructural Protein p7 and Host Proteins
Classical swine fever (CSF) is a highly contagious viral disease causing severe economic losses to the swine industry. As viroporins of viruses modulate the cellular ion balance and then take over the cellular machinery, blocking the activity of viroporin or developing viroporin-defective attenuated vaccines offers new approaches to treat or prevent viral infection. Non-structural protein p7 of CSF virus (CSFV) is a viroporin, which was highly involved in CSFV virulence. Deciphering the interaction between p7 and host proteins will aid our understanding of the mechanism of p7-cellular protein interaction affecting CSFV rep...
Source: Frontiers in Microbiology - November 30, 2020 Category: Microbiology Source Type: research

Endovascular model of abdominal aortic aneurysm induction in swine
Abdominal aortic aneurysms are among the main causes of death. The high morbidity and mortality associated with aneurysm rupture and repair represents a challenge for surgeons and high risk for patients. Although experimental models are useful to understand, train, and develop new treatment and diagnostic methods for this pathology, animal models developed to date are far from ideal. Animals are either too small and do not represent the pathology of humans, or the procedures employ laparotomy, or the aortic behavior does not resemble that of a true aneurysm. We developed a novel, less invasive and effective method to induc...
Source: Vascular Medicine recent issues - May 30, 2014 Category: Internal Medicine Authors: Lederman, A., Saliture Neto, F. T., Ferreira, R., de Figueiredo, L. F. P., Otoch, J. P., Aun, R., da Silva, E. S. Tags: Original Articles Source Type: research